diff --git a/packages/mysql-on-sqlite/src/sqlite/class-wp-sqlite-information-schema-builder.php b/packages/mysql-on-sqlite/src/sqlite/class-wp-sqlite-information-schema-builder.php
index bbd3728fb..9cd5c3dfd 100644
--- a/packages/mysql-on-sqlite/src/sqlite/class-wp-sqlite-information-schema-builder.php
+++ b/packages/mysql-on-sqlite/src/sqlite/class-wp-sqlite-information-schema-builder.php
@@ -1820,9 +1820,10 @@ private function extract_referential_constraint_data( WP_Parser_Node $node, stri
 				continue;
 			}
 
+			// Column names are case-insensitive in MySQL.
 			$is_prefix = true;
 			foreach ( $reference_parts as $i => $reference_part ) {
-				if ( $index_columns[ $i ] !== $this->get_value( $reference_part ) ) {
+				if ( 0 !== strcasecmp( $index_columns[ $i ], $this->get_value( $reference_part ) ) ) {
 					$is_prefix = false;
 					break;
 				}
diff --git a/packages/mysql-on-sqlite/tests/WP_MySQL_On_SQLite_Metadata_Tests.php b/packages/mysql-on-sqlite/tests/WP_MySQL_On_SQLite_Metadata_Tests.php
index 7dfb79548..1215dd288 100644
--- a/packages/mysql-on-sqlite/tests/WP_MySQL_On_SQLite_Metadata_Tests.php
+++ b/packages/mysql-on-sqlite/tests/WP_MySQL_On_SQLite_Metadata_Tests.php
@@ -1943,6 +1943,53 @@ public function testInformationSchemaForeignKeysReferencingShorterUniqueKey(): v
 		);
 	}
 
+	public function testInformationSchemaForeignKeysReferencingColumnsInDifferentLetterCase(): void {
+		$this->assertQuery(
+			'CREATE TABLE t1 (
+				id INT PRIMARY KEY,
+				code INT,
+				a INT NOT NULL,
+				b INT NOT NULL,
+				UNIQUE KEY u_code (code),
+				UNIQUE KEY u_a_b (a, b)
+			)'
+		);
+		$this->assertQuery(
+			'CREATE TABLE t2 (
+				t1_id INT,
+				x INT,
+				y INT,
+				FOREIGN KEY (t1_id) REFERENCES t1 (ID),
+				FOREIGN KEY (x, y) REFERENCES t1 (A, b)
+			)'
+		);
+		$this->assertQuery( 'ALTER TABLE t2 ADD COLUMN z INT, ADD CONSTRAINT fk_z FOREIGN KEY (z) REFERENCES t1 (CoDe)' );
+
+		$result = $this->assertQuery(
+			"SELECT constraint_name, unique_constraint_name
+			FROM information_schema.referential_constraints
+			WHERE table_name = 't2'
+			ORDER BY constraint_name"
+		);
+		$this->assertEquals(
+			array(
+				(object) array(
+					'CONSTRAINT_NAME'        => 'fk_z',
+					'UNIQUE_CONSTRAINT_NAME' => 'u_code',
+				),
+				(object) array(
+					'CONSTRAINT_NAME'        => 't2_ibfk_1',
+					'UNIQUE_CONSTRAINT_NAME' => 'PRIMARY',
+				),
+				(object) array(
+					'CONSTRAINT_NAME'        => 't2_ibfk_2',
+					'UNIQUE_CONSTRAINT_NAME' => 'u_a_b',
+				),
+			),
+			$result
+		);
+	}
+
 	public function testInformationSchemaAlterTableAddForeignKeys(): void {
 		$this->assertQuery( 'CREATE TABLE t1 (id INT PRIMARY KEY, name VARCHAR(255))' );
 		$this->assertQuery( 'CREATE TABLE t2 (id INT)' );