diff --git a/CHANGELOG.md b/CHANGELOG.md
index 0a45ec3fe3..cc8e5e0969 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,6 +2,10 @@
 
 ## Unreleased
 
+### Fixes
+
+- Skip Android profiling when the installed system profiling package delivers empty traces ([#5975](https://github.com/getsentry/sentry-java/pull/5975))
+
 ### Dependencies
 
 - Bump Native SDK from v0.16.2 to v0.16.3 ([#5962](https://github.com/getsentry/sentry-java/pull/5962))
diff --git a/sentry-android-core/src/main/java/io/sentry/android/core/PerfettoProfiler.java b/sentry-android-core/src/main/java/io/sentry/android/core/PerfettoProfiler.java
index d09c725269..3bcd6450f6 100644
--- a/sentry-android-core/src/main/java/io/sentry/android/core/PerfettoProfiler.java
+++ b/sentry-android-core/src/main/java/io/sentry/android/core/PerfettoProfiler.java
@@ -2,6 +2,8 @@
 
 import android.annotation.SuppressLint;
 import android.content.Context;
+import android.content.pm.PackageInfo;
+import android.content.pm.PackageManager;
 import android.os.Build;
 import android.os.Bundle;
 import android.os.CancellationSignal;
@@ -11,6 +13,7 @@
 import io.sentry.ILogger;
 import io.sentry.ISentryExecutorService;
 import io.sentry.SentryLevel;
+import io.sentry.android.core.util.AndroidLazyEvaluator;
 import java.io.File;
 import java.util.concurrent.RejectedExecutionException;
 import java.util.function.Consumer;
@@ -41,9 +44,29 @@ public class PerfettoProfiler {
 
   private static final long RESULT_TIMEOUT_MS = 5000;
 
+  /** Name of the APEX that provides {@link ProfilingManager}. */
+  private static final String PROFILING_PACKAGE_NAME = "com.google.android.profiling";
+
+  /**
+   * This version of the profiling package accepts profiling requests, but delivers empty traces.
+   */
+  private static final long EMPTY_TRACE_PROFILING_PACKAGE_VERSION = 370546200L;
+
+  /** Used when the profiling package is not installed, or its version cannot be read. */
+  private static final long UNKNOWN_PROFILING_PACKAGE_VERSION = 0L;
+
+  /**
+   * A new profiler is created for each profile chunk, but the profiling package cannot change while
+   * the process runs, as an update of it restarts the app. Thus, we read it only once, to avoid a
+   * binder call per chunk.
+   */
+  private static final @NotNull AndroidLazyEvaluator<Long> profilingPackageVersionEvaluator =
+      new AndroidLazyEvaluator<>(PerfettoProfiler::resolveProfilingPackageVersion);
+
   private final @NotNull ILogger logger;
   private final @NotNull ISentryExecutorService executorService;
   private final @Nullable ProfilingManager profilingManager;
+  private final long profilingPackageVersion;
   private final @NotNull CancellationSignal cancellationSignal = new CancellationSignal();
 
   private final @NotNull Object profilingResultLock = new Object();
@@ -60,16 +83,19 @@ public PerfettoProfiler(
     this(
         logger,
         executorService,
-        (ProfilingManager) context.getSystemService(Context.PROFILING_SERVICE));
+        (ProfilingManager) context.getSystemService(Context.PROFILING_SERVICE),
+        getProfilingPackageVersion(context));
   }
 
   PerfettoProfiler(
       final @NotNull ILogger logger,
       final @NotNull ISentryExecutorService executorService,
-      final @Nullable ProfilingManager profilingManager) {
+      final @Nullable ProfilingManager profilingManager,
+      final long profilingPackageVersion) {
     this.logger = logger;
     this.executorService = executorService;
     this.profilingManager = profilingManager;
+    this.profilingPackageVersion = profilingPackageVersion;
   }
 
   public boolean start(final long durationMs) {
@@ -84,6 +110,14 @@ public boolean start(final long durationMs) {
       return false;
     }
 
+    if (profilingPackageVersion == EMPTY_TRACE_PROFILING_PACKAGE_VERSION) {
+      logger.log(
+          SentryLevel.WARNING,
+          "Android profiling package version %d delivers empty traces. Profiling is disabled.",
+          profilingPackageVersion);
+      return false;
+    }
+
     final Bundle params = new Bundle();
     params.putInt(KEY_DURATION_MS, (int) durationMs);
     params.putInt(KEY_FREQUENCY_HZ, PROFILING_FREQUENCY_HZ);
@@ -216,6 +250,26 @@ private void deleteTraceFile(final @Nullable File traceFile) {
     return traceFile;
   }
 
+  private static long getProfilingPackageVersion(final @NotNull Context context) {
+    final @Nullable Long version = profilingPackageVersionEvaluator.getValue(context);
+    return version != null ? version : UNKNOWN_PROFILING_PACKAGE_VERSION;
+  }
+
+  private static @NotNull Long resolveProfilingPackageVersion(final @NotNull Context context) {
+    try {
+      final @NotNull PackageInfo packageInfo =
+          context
+              .getPackageManager()
+              .getPackageInfo(
+                  PROFILING_PACKAGE_NAME,
+                  PackageManager.PackageInfoFlags.of(PackageManager.MATCH_APEX));
+      return packageInfo.getLongVersionCode();
+    } catch (PackageManager.NameNotFoundException e) {
+      // The profiling package is not installed on this device
+      return UNKNOWN_PROFILING_PACKAGE_VERSION;
+    }
+  }
+
   private static @NotNull String errorCodeToString(final int errorCode) {
     switch (errorCode) {
       case ProfilingResult.ERROR_FAILED_RATE_LIMIT_PROCESS:
diff --git a/sentry-android-core/src/test/java/io/sentry/android/core/PerfettoProfilerTest.kt b/sentry-android-core/src/test/java/io/sentry/android/core/PerfettoProfilerTest.kt
index 0746d36dff..e11f63e79f 100644
--- a/sentry-android-core/src/test/java/io/sentry/android/core/PerfettoProfilerTest.kt
+++ b/sentry-android-core/src/test/java/io/sentry/android/core/PerfettoProfilerTest.kt
@@ -23,6 +23,8 @@ import org.junit.runner.RunWith
 import org.mockito.kotlin.any
 import org.mockito.kotlin.doAnswer
 import org.mockito.kotlin.mock
+import org.mockito.kotlin.never
+import org.mockito.kotlin.verify
 import org.mockito.kotlin.whenever
 import org.robolectric.annotation.Config
 
@@ -52,8 +54,11 @@ class PerfettoProfilerTest {
     context = ApplicationProvider.getApplicationContext()
   }
 
-  private fun getSut(profilingManager: ProfilingManager? = mockProfilingManager): PerfettoProfiler {
-    return PerfettoProfiler(mockLogger, executor, profilingManager)
+  private fun getSut(
+    profilingManager: ProfilingManager? = mockProfilingManager,
+    profilingPackageVersion: Long = 0L,
+  ): PerfettoProfiler {
+    return PerfettoProfiler(mockLogger, executor, profilingManager, profilingPackageVersion)
   }
 
   private fun createTraceFile(): File {
@@ -94,6 +99,22 @@ class PerfettoProfilerTest {
     assertFalse(profiler.start(60000))
   }
 
+  @Test
+  fun `start returns false and does not request profiling for unsupported package version`() {
+    val profiler = getSut(profilingPackageVersion = 370546200L)
+
+    assertFalse(profiler.start(60000))
+    verify(mockProfilingManager, never()).requestProfiling(any(), any(), any(), any(), any(), any())
+  }
+
+  @Test
+  fun `start requests profiling for other package versions`() {
+    val profiler = getSut(profilingPackageVersion = 370546201L)
+
+    assertTrue(profiler.start(60000))
+    verify(mockProfilingManager).requestProfiling(any(), any(), any(), any(), any(), any())
+  }
+
   @Test
   fun `endAndCollect calls listener with null when never started`() {
     val profiler = getSut()