diff --git a/dev-packages/browser-integration-tests/suites/wasm/instantiateBufferRegistration/init.js b/dev-packages/browser-integration-tests/suites/wasm/instantiateBufferRegistration/init.js
new file mode 100644
index 000000000000..d5c0d011b788
--- /dev/null
+++ b/dev-packages/browser-integration-tests/suites/wasm/instantiateBufferRegistration/init.js
@@ -0,0 +1,20 @@
+import * as Sentry from '@sentry/browser';
+import { registerWebWorkerWasm } from '@sentry/wasm';
+
+window.Sentry = Sentry;
+
+Sentry.init({
+  traceLifecycle: 'static',
+  dsn: 'https://public@dsn.ingest.sentry.io/1337',
+});
+
+// `registerWebWorkerWasm` installs the same patches a worker would, and reports
+// every registered module to the scope it is given. Collecting them here is the
+// only way to observe registration from the page, since main-thread images stay
+// module-internal until a frame matches one.
+window.registeredImages = [];
+registerWebWorkerWasm({
+  self: {
+    postMessage: message => window.registeredImages.push(...(message._sentryWasmImages || [])),
+  },
+});
diff --git a/dev-packages/browser-integration-tests/suites/wasm/instantiateBufferRegistration/subject.js b/dev-packages/browser-integration-tests/suites/wasm/instantiateBufferRegistration/subject.js
new file mode 100644
index 000000000000..d58714c72fca
--- /dev/null
+++ b/dev-packages/browser-integration-tests/suites/wasm/instantiateBufferRegistration/subject.js
@@ -0,0 +1,12 @@
+window.loadWasmFromBuffer = async () => {
+  const response = await fetch('https://localhost:5887/simple.wasm');
+  const buffer = await response.arrayBuffer();
+
+  await WebAssembly.instantiate(new Uint8Array(buffer), {
+    env: {
+      external_func: () => {},
+    },
+  });
+
+  return window.registeredImages;
+};
diff --git a/dev-packages/browser-integration-tests/suites/wasm/instantiateBufferRegistration/test.ts b/dev-packages/browser-integration-tests/suites/wasm/instantiateBufferRegistration/test.ts
new file mode 100644
index 000000000000..df95edceaf52
--- /dev/null
+++ b/dev-packages/browser-integration-tests/suites/wasm/instantiateBufferRegistration/test.ts
@@ -0,0 +1,48 @@
+import type { Page, Route } from '@playwright/test';
+import { expect } from '@playwright/test';
+import fs from 'fs';
+import path from 'path';
+import { sentryTest } from '../../../utils/fixtures';
+import { shouldSkipWASMTests } from '../../../utils/wasmHelpers';
+
+function serveWasmFixture(page: Page): Promise<void> {
+  return page.route('**/simple.wasm', (route: Route) => {
+    const wasmModule = fs.readFileSync(path.resolve(__dirname, '..', 'simple.wasm'));
+
+    return route.fulfill({
+      status: 200,
+      body: wasmModule,
+      headers: {
+        'Content-Type': 'application/wasm',
+      },
+    });
+  });
+}
+
+sentryTest(
+  'registers a module loaded via fetch, arrayBuffer and instantiate under its response url',
+  async ({ getLocalTestUrl, page, browserName }) => {
+    if (shouldSkipWASMTests(browserName)) {
+      sentryTest.skip();
+    }
+
+    const url = await getLocalTestUrl({ testDir: __dirname });
+    await serveWasmFixture(page);
+    await page.goto(url);
+
+    const images = await page.evaluate(async () => {
+      // @ts-expect-error this function exists
+      return window.loadWasmFromBuffer();
+    });
+
+    expect(images).toEqual([
+      {
+        type: 'wasm',
+        code_file: 'https://localhost:5887/simple.wasm',
+        code_id: '0ba020cdd2444f7eafdd25999a8e9010',
+        debug_file: null,
+        debug_id: '0ba020cdd2444f7eafdd25999a8e90100',
+      },
+    ]);
+  },
+);
diff --git a/packages/wasm/src/patchWasmResponse.ts b/packages/wasm/src/patchWasmResponse.ts
new file mode 100644
index 000000000000..e4117117a118
--- /dev/null
+++ b/packages/wasm/src/patchWasmResponse.ts
@@ -0,0 +1,103 @@
+import { addNonEnumerableProperty, fill } from '@sentry/core';
+
+/**
+ * Streaming wasm registration (`instantiateStreaming` / `compileStreaming`) reads the module URL
+ * from `Response.url`. Non-streaming paths (`WebAssembly.instantiate` / `compile` with bytes) only
+ * receive a buffer — no URL — so registration would otherwise be skipped.
+ *
+ * This module patches `Response.prototype.arrayBuffer` and `bytes` so that when wasm is fetched
+ * and then loaded from bytes, we can map the resulting `ArrayBuffer` back to the fetch URL via
+ * `getWasmSourceUrl()` and register the module in `patchNonStreamingWebAssembly`.
+ */
+const wasmSourceUrls = new WeakMap<ArrayBuffer, string>();
+
+const PATCHED_SYMBOL = Symbol.for('__sentryWasmPatched');
+
+type MaybePatched = { [PATCHED_SYMBOL]?: boolean };
+
+/**
+ * Resolves a wasm source buffer back to its fetch URL, when known.
+ */
+export function getWasmSourceUrl(source: BufferSource): string | undefined {
+  const buffer = toArrayBuffer(source);
+  if (!buffer) {
+    return undefined;
+  }
+
+  return wasmSourceUrls.get(buffer);
+}
+
+function toArrayBuffer(source: BufferSource): ArrayBuffer | undefined {
+  if (source instanceof ArrayBuffer) {
+    return source;
+  }
+
+  if (ArrayBuffer.isView(source)) {
+    const { buffer } = source;
+    return buffer instanceof ArrayBuffer ? buffer : undefined;
+  }
+
+  return undefined;
+}
+
+function looksLikeWasmResponse(response: Response): boolean {
+  const contentType = response.headers.get('content-type');
+  if (contentType?.includes('application/wasm')) {
+    return true;
+  }
+
+  const { url } = response;
+  return Boolean(url && /\.wasm(?:\?|#|$)/i.test(url));
+}
+
+function tagResponseBuffer(response: Response, buffer: ArrayBuffer): void {
+  if (looksLikeWasmResponse(response) && response.url) {
+    wasmSourceUrls.set(buffer, response.url);
+  }
+}
+
+/**
+ * Patches Response body readers so wasm bytes remember their fetch URL.
+ */
+export function patchWasmResponseBodyReaders(): void {
+  if (typeof Response === 'undefined') {
+    return;
+  }
+
+  const responseProto = Response.prototype as MaybePatched;
+  if (responseProto[PATCHED_SYMBOL]) {
+    return;
+  }
+
+  fill(Response.prototype, 'arrayBuffer', (original: (this: Response) => Promise<ArrayBuffer>) => {
+    return function arrayBuffer(this: Response): Promise<ArrayBuffer> {
+      const bufferPromise: Promise<ArrayBuffer> = original.call(this);
+      return bufferPromise.then((buffer: ArrayBuffer) => {
+        tagResponseBuffer(this, buffer);
+        return buffer;
+      });
+    };
+  });
+
+  fill(Response.prototype, 'bytes', (original: (this: Response) => Promise<Uint8Array>) => {
+    return function bytes(this: Response): Promise<Uint8Array> {
+      const bytesPromise: Promise<Uint8Array> = original.call(this);
+      return bytesPromise.then((bytes: Uint8Array) => {
+        const { buffer } = bytes;
+        if (buffer instanceof ArrayBuffer) {
+          tagResponseBuffer(this, buffer);
+        }
+        return bytes;
+      });
+    };
+  });
+
+  addNonEnumerableProperty(responseProto, PATCHED_SYMBOL, true);
+}
+
+/** @internal */
+export function _resetResponsePatchForTests(): void {
+  if (typeof Response !== 'undefined') {
+    addNonEnumerableProperty(Response.prototype, PATCHED_SYMBOL, false);
+  }
+}
diff --git a/packages/wasm/src/patchWebAssembly.ts b/packages/wasm/src/patchWebAssembly.ts
index e4f7b527a2a0..005a749c618b 100644
--- a/packages/wasm/src/patchWebAssembly.ts
+++ b/packages/wasm/src/patchWebAssembly.ts
@@ -1,5 +1,9 @@
+import { getWasmSourceUrl, patchWasmResponseBodyReaders } from './patchWasmResponse';
+
 export type RegisterModuleCallback = (module: WebAssembly.Module, url: string) => void;
 
+let nonStreamingPatched = false;
+
 /**
  * Patches the WebAssembly streaming APIs so that every compiled module gets
  * registered as a debug image under the URL of the response it was compiled
@@ -7,7 +11,7 @@ export type RegisterModuleCallback = (module: WebAssembly.Module, url: string) =
  *
  * @param registerModule callback invoked for every successfully compiled module
  */
-export function patchWebAssembly(registerModule: RegisterModuleCallback): void {
+export function patchStreamingWebAssembly(registerModule: RegisterModuleCallback): void {
   if ('instantiateStreaming' in WebAssembly) {
     const origInstantiateStreaming = WebAssembly.instantiateStreaming as (
       response: unknown,
@@ -56,3 +60,64 @@ function registerSafely(registerModule: RegisterModuleCallback, module: WebAssem
     // a registration failure must never break the user's WebAssembly call
   }
 }
+
+function registerFromBufferSource(
+  registerModule: RegisterModuleCallback,
+  module: WebAssembly.Module,
+  source: BufferSource,
+): void {
+  const url = getWasmSourceUrl(source);
+  if (url) {
+    registerSafely(registerModule, module, url);
+  }
+}
+
+/**
+ * Patches the non-streaming web assembly runtime.
+ */
+function patchNonStreamingWebAssembly(registerModule: RegisterModuleCallback): void {
+  if (nonStreamingPatched) {
+    return;
+  }
+
+  nonStreamingPatched = true;
+
+  // Double-cast, because the overloaded native signature (buffer vs. module
+  // first argument) cannot be widened to a pass-through shape in one step.
+  const origInstantiate = WebAssembly.instantiate as unknown as (
+    source: unknown,
+    ...rest: unknown[]
+  ) => Promise<WebAssembly.WebAssemblyInstantiatedSource>;
+  WebAssembly.instantiate = function instantiate(source: BufferSource | WebAssembly.Module, ...rest: unknown[]) {
+    if (source instanceof WebAssembly.Module) {
+      return origInstantiate(source, ...rest);
+    }
+
+    return origInstantiate(source, ...rest).then(result => {
+      registerFromBufferSource(registerModule, result.module, source);
+      return result;
+    });
+  } as typeof WebAssembly.instantiate;
+
+  const origCompile = WebAssembly.compile as (source: unknown, ...rest: unknown[]) => Promise<WebAssembly.Module>;
+  WebAssembly.compile = function compile(source: BufferSource, ...rest: unknown[]): Promise<WebAssembly.Module> {
+    return origCompile(source, ...rest).then(module => {
+      registerFromBufferSource(registerModule, module, source);
+      return module;
+    });
+  };
+}
+
+/**
+ * Patches the web assembly runtime.
+ */
+export function patchWebAssembly(registerModule: RegisterModuleCallback): void {
+  patchWasmResponseBodyReaders();
+  patchNonStreamingWebAssembly(registerModule);
+  patchStreamingWebAssembly(registerModule);
+}
+
+/** @internal */
+export function _resetNonStreamingPatchForTests(): void {
+  nonStreamingPatched = false;
+}
diff --git a/packages/wasm/test/frozenResponse.test.ts b/packages/wasm/test/frozenResponse.test.ts
new file mode 100644
index 000000000000..a74a67d6b44b
--- /dev/null
+++ b/packages/wasm/test/frozenResponse.test.ts
@@ -0,0 +1,21 @@
+import { describe, expect, it, vi } from 'vitest';
+import { patchWebAssembly } from '../src/patchWebAssembly';
+
+// Kept in its own file because freezing `Response.prototype` cannot be undone
+// and would leak into every other test sharing the environment.
+describe('patchWebAssembly() with a frozen Response.prototype', () => {
+  it('does not throw and still installs the streaming patch', async () => {
+    Object.freeze(Response.prototype);
+
+    const module = {} as WebAssembly.Module;
+    WebAssembly.compileStreaming = vi.fn().mockResolvedValue(module) as unknown as typeof WebAssembly.compileStreaming;
+
+    const registered: string[] = [];
+
+    expect(() => patchWebAssembly((_module, url) => registered.push(url))).not.toThrow();
+
+    await WebAssembly.compileStreaming({ url: 'http://localhost:8001/main.wasm' } as Response);
+
+    expect(registered).toEqual(['http://localhost:8001/main.wasm']);
+  });
+});
diff --git a/packages/wasm/test/patchWebAssembly.test.ts b/packages/wasm/test/patchWebAssembly.test.ts
index 6a4e46c9364f..29eaef416d56 100644
--- a/packages/wasm/test/patchWebAssembly.test.ts
+++ b/packages/wasm/test/patchWebAssembly.test.ts
@@ -1,16 +1,47 @@
-import { afterEach, describe, expect, it, vi } from 'vitest';
+import fs from 'node:fs';
+import path from 'node:path';
+import { fileURLToPath } from 'node:url';
+import { afterAll, afterEach, beforeAll, beforeEach, describe, expect, it, vi } from 'vitest';
 import { patchWebAssembly } from '../src/patchWebAssembly';
+import { getImage, IMAGES, registerModule } from '../src/registry';
+import { restoreWasmGlobals, saveWasmGlobals } from './wasmTestHelpers';
 
 const RESPONSE = { url: 'http://localhost:8001/main.wasm' } as Response;
 const MODULE = {} as WebAssembly.Module;
 
-describe('patchWebAssembly()', () => {
-  const originalInstantiateStreaming = WebAssembly.instantiateStreaming;
-  const originalCompileStreaming = WebAssembly.compileStreaming;
+const testDir = path.dirname(fileURLToPath(import.meta.url));
+const SIMPLE_WASM_PATH = path.resolve(
+  testDir,
+  '../../../dev-packages/browser-integration-tests/suites/wasm/simple.wasm',
+);
+
+const WASM_URL = 'https://example.com/simple.wasm';
+
+const WASM_IMPORTS = {
+  env: {
+    external_func: () => {},
+  },
+};
+
+async function loadWasmBytes(): Promise<Uint8Array> {
+  return new Uint8Array(fs.readFileSync(SIMPLE_WASM_PATH));
+}
+
+async function fetchWasmBytes(): Promise<ArrayBuffer> {
+  const bytes = await loadWasmBytes();
+  const response = new Response(bytes, {
+    headers: { 'Content-Type': 'application/wasm' },
+  });
+  Object.defineProperty(response, 'url', { value: WASM_URL });
+
+  return response.arrayBuffer();
+}
+
+describe('patchWebAssembly() streaming registration', () => {
+  const savedGlobals = saveWasmGlobals();
 
   afterEach(() => {
-    WebAssembly.instantiateStreaming = originalInstantiateStreaming;
-    WebAssembly.compileStreaming = originalCompileStreaming;
+    restoreWasmGlobals(savedGlobals);
   });
 
   it('forwards every argument to instantiateStreaming and registers the module', async () => {
@@ -70,3 +101,104 @@ describe('patchWebAssembly()', () => {
     await expect(WebAssembly.compileStreaming(RESPONSE)).resolves.toBe(MODULE);
   });
 });
+
+describe('patchWebAssembly() non-streaming registration', () => {
+  const savedGlobals = saveWasmGlobals();
+
+  beforeAll(() => {
+    patchWebAssembly(registerModule);
+  });
+
+  afterAll(() => {
+    restoreWasmGlobals(savedGlobals);
+  });
+
+  beforeEach(() => {
+    IMAGES.length = 0;
+  });
+
+  it('registers modules loaded via fetch → arrayBuffer → instantiate', async () => {
+    const buffer = await fetchWasmBytes();
+
+    await WebAssembly.instantiate(buffer, WASM_IMPORTS);
+
+    expect(getImage(WASM_URL)).toBe(0);
+    expect(IMAGES[0]?.code_file).toBe(WASM_URL);
+    expect(IMAGES[0]?.code_id).toBe('0ba020cdd2444f7eafdd25999a8e9010');
+  });
+
+  it('registers modules loaded via fetch → arrayBuffer → Uint8Array → instantiate', async () => {
+    const buffer = await fetchWasmBytes();
+    const view = new Uint8Array(buffer);
+
+    await WebAssembly.instantiate(view, WASM_IMPORTS);
+
+    expect(getImage(WASM_URL)).toBe(0);
+    expect(IMAGES[0]?.code_file).toBe(WASM_URL);
+  });
+
+  it('registers modules loaded via fetch → arrayBuffer → compile', async () => {
+    const buffer = await fetchWasmBytes();
+
+    await WebAssembly.compile(buffer);
+
+    expect(getImage(WASM_URL)).toBe(0);
+    expect(IMAGES[0]?.code_file).toBe(WASM_URL);
+  });
+
+  it('does not register modules when the buffer has no tagged URL', async () => {
+    const bytes = await loadWasmBytes();
+
+    await WebAssembly.instantiate(bytes, WASM_IMPORTS);
+
+    expect(IMAGES).toHaveLength(0);
+  });
+});
+
+describe('patchWebAssembly() non-streaming argument forwarding', () => {
+  const savedGlobals = saveWasmGlobals();
+
+  afterEach(() => {
+    restoreWasmGlobals(savedGlobals);
+  });
+
+  it('forwards every argument to instantiate', async () => {
+    const orig = vi.fn().mockResolvedValue({ module: MODULE, instance: {} });
+    WebAssembly.instantiate = orig as unknown as typeof WebAssembly.instantiate;
+
+    patchWebAssembly(registerModule);
+
+    const bytes = new Uint8Array(8);
+    const compileOptions = { builtins: ['js-string'] };
+    await (WebAssembly.instantiate as unknown as (...args: unknown[]) => Promise<unknown>)(
+      bytes,
+      WASM_IMPORTS,
+      compileOptions,
+    );
+
+    expect(orig).toHaveBeenCalledWith(bytes, WASM_IMPORTS, compileOptions);
+  });
+
+  it('forwards every argument to compile', async () => {
+    const orig = vi.fn().mockResolvedValue(MODULE);
+    WebAssembly.compile = orig as unknown as typeof WebAssembly.compile;
+
+    patchWebAssembly(registerModule);
+
+    const bytes = new Uint8Array(8);
+    const compileOptions = { builtins: ['js-string'] };
+    await (WebAssembly.compile as unknown as (...args: unknown[]) => Promise<unknown>)(bytes, compileOptions);
+
+    expect(orig).toHaveBeenCalledWith(bytes, compileOptions);
+  });
+
+  it('resolves the original result even if registration throws', async () => {
+    patchWebAssembly(() => {
+      throw new Error('registration failed');
+    });
+
+    const buffer = await fetchWasmBytes();
+
+    await expect(WebAssembly.compile(buffer)).resolves.toBeInstanceOf(WebAssembly.Module);
+  });
+});
diff --git a/packages/wasm/test/wasmTestHelpers.ts b/packages/wasm/test/wasmTestHelpers.ts
new file mode 100644
index 000000000000..c8d343806037
--- /dev/null
+++ b/packages/wasm/test/wasmTestHelpers.ts
@@ -0,0 +1,39 @@
+import { _resetResponsePatchForTests } from '../src/patchWasmResponse';
+import { _resetNonStreamingPatchForTests } from '../src/patchWebAssembly';
+
+export type SavedWasmGlobals = {
+  instantiate: typeof WebAssembly.instantiate;
+  compile: typeof WebAssembly.compile;
+  instantiateStreaming?: typeof WebAssembly.instantiateStreaming;
+  compileStreaming?: typeof WebAssembly.compileStreaming;
+  arrayBuffer: typeof Response.prototype.arrayBuffer;
+  bytes?: typeof Response.prototype.bytes;
+};
+
+export function saveWasmGlobals(): SavedWasmGlobals {
+  return {
+    instantiate: WebAssembly.instantiate,
+    compile: WebAssembly.compile,
+    instantiateStreaming: WebAssembly.instantiateStreaming,
+    compileStreaming: WebAssembly.compileStreaming,
+    arrayBuffer: Response.prototype.arrayBuffer,
+    bytes: 'bytes' in Response.prototype ? Response.prototype.bytes : undefined,
+  };
+}
+
+export function restoreWasmGlobals(saved: SavedWasmGlobals): void {
+  WebAssembly.instantiate = saved.instantiate;
+  WebAssembly.compile = saved.compile;
+  if (saved.instantiateStreaming) {
+    WebAssembly.instantiateStreaming = saved.instantiateStreaming;
+  }
+  if (saved.compileStreaming) {
+    WebAssembly.compileStreaming = saved.compileStreaming;
+  }
+  Response.prototype.arrayBuffer = saved.arrayBuffer;
+  if (saved.bytes) {
+    Response.prototype.bytes = saved.bytes;
+  }
+  _resetNonStreamingPatchForTests();
+  _resetResponsePatchForTests();
+}
diff --git a/packages/wasm/test/webworker.test.ts b/packages/wasm/test/webworker.test.ts
index afaa5d999966..a4b42aefd77c 100644
--- a/packages/wasm/test/webworker.test.ts
+++ b/packages/wasm/test/webworker.test.ts
@@ -1,14 +1,22 @@
 import type { DebugImage, StackFrame } from '@sentry/core';
 import { GLOBAL_OBJ } from '@sentry/core';
-import { afterEach, describe, expect, it, vi } from 'vitest';
+import { afterEach, beforeEach, describe, expect, it, vi } from 'vitest';
 import { patchFrames, registerWebWorkerWasm } from '../src/index';
+import { restoreWasmGlobals, saveWasmGlobals } from './wasmTestHelpers';
 
 const WINDOW = GLOBAL_OBJ as typeof GLOBAL_OBJ & {
   _sentryWasmImages?: Array<DebugImage>;
 };
 
 describe('registerWebWorkerWasm()', () => {
+  let savedGlobals = saveWasmGlobals();
+
+  beforeEach(() => {
+    savedGlobals = saveWasmGlobals();
+  });
+
   afterEach(() => {
+    restoreWasmGlobals(savedGlobals);
     delete WINDOW._sentryWasmImages;
     vi.restoreAllMocks();
   });
@@ -18,12 +26,12 @@ describe('registerWebWorkerWasm()', () => {
     const mockSelf = { postMessage: mockPostMessage };
 
     const originalInstantiateStreaming = WebAssembly.instantiateStreaming;
+    const originalInstantiate = WebAssembly.instantiate;
 
     registerWebWorkerWasm({ self: mockSelf });
 
     expect(WebAssembly.instantiateStreaming).not.toBe(originalInstantiateStreaming);
-
-    WebAssembly.instantiateStreaming = originalInstantiateStreaming;
+    expect(WebAssembly.instantiate).not.toBe(originalInstantiate);
   });
 
   it('should patch WebAssembly.compileStreaming when available', () => {
@@ -35,8 +43,6 @@ describe('registerWebWorkerWasm()', () => {
     registerWebWorkerWasm({ self: mockSelf });
 
     expect(WebAssembly.compileStreaming).not.toBe(originalCompileStreaming);
-
-    WebAssembly.compileStreaming = originalCompileStreaming;
   });
 });