MD Candidate & Computational Oncology Researcher · Università degli Studi di Napoli Federico II
Computational oncology, spatial multi-omics, reaction-diffusion biophysics & reproducible software.
Founder of Web3 protocol @arbincept.
🌐 The Cave (Research Portfolio) · 📝 Substack · 💼 LinkedIn · 🆔 ORCID · 🤗 Hugging Face
🌐 Interactive 3D WebGL Twin & Lab · ⭐ Inflammatory Onco-Physics Repo · ⚡ 1-Click Colab Solver · 📄 Research Square Preprint (10.21203/rs.3.rs-11695210/v1)
5-Part 4K Simulation Series (YouTube Shorts):
Part 1: Perivascular Sanctuaries · Part 2: Matrix Breach & ctDNA · Part 3: Desmoplastic Shield · Part 4: Targeted Antibody Influx · Part 5: 5.5-Month ctDNA Lead Time
Author-reviewed clinical & biophysical lay summary (Conditions for Pharmacological Sanctuaries in Perivascular Tumour Cords, rs-11530312) by Dr. Luc Hendriks, PhD & Luca Celebrano:
Also translated into 11 languages:
🇮🇳 हिन्दी (Hindi) · 🇮🇹 Italiano · 🇪🇸 Español · 🇫🇷 Français · 🇩🇪 Deutsch · 🇵🇹 Português · 🇨🇳 中文 · 🇯🇵 日本語 · 🇰🇷 한국어 · 🇸🇦 العربية · 🇳🇱 Nederlands
1. 🏆 Inflammatory Onco-Physics (Flagship)
A Reaction-Diffusion Theory of Microvascular Pharmacological Sanctuaries and Inflammatory Pre-conditioning Explains Post-Adjuvant Relapse Dynamics Across 3,461 Patients.
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Setting & Scope: Explains post-cessation recurrence and ctDNA shedding kinetics across 11 clinical cohorts (
$N=3,461$ ) through continuous reaction-diffusion (Bessel K₀) and hereditary Volterra memory functional. - Status: Springer Nature Master Monograph (26 pages) / Zenodo Permanent Archive.
- Access: Research Square Preprint (DOI: 10.21203/rs.3.rs-11695210/v1) · Zenodo Master Archive (DOI: 10.5281/zenodo.24118328) · 1-Click Google Colab (Pro T4 GPU) · Full Monograph PDF · Supplementary Information PDF · Executive Memorandum PDF · 5-Part 4K Simulation Series
An in silico biophysical reaction-diffusion theory of pharmacological sanctuaries, post-ADAURA recurrence kinetics, and the prospective SG-ADAURA trial protocol hypothesis.
- Status: Under review at Scientific Reports (Nature Portfolio, Editor Assigned).
- Access: Research Square Preprint (DOI: 10.21203/rs.3.rs-11530312/v1) · Zenodo Master Archive · Full Manuscript PDF · Interactive Slides · Poster · bio.tools
Evidence-linked translational models, exploratory GIST phenotype scoring, candidate registry, and Composite Resistance Index (CRI) audit tools.
- Status: Published on Research Square.
- Access: Preprint (DOI: 10.21203/rs.3.rs-11633521/v1) · Zenodo Archive · bio.tools
4. 🎲 InSituGame
Spatial evolutionary game-theoretic assay for inferring subclonal payoff matrices and adaptive therapy dynamics.
- Access: Live Assay Portal · Zenodo Archive · bio.tools
5. 🧭 Spatial Architecture
Subcellular transport boundaries in EGFR-mutant NSCLC via 10x Visium HD (officially curated in awesome-single-cell).
6. 👁️ InSituVision-AI
Low-cost Attention-MIL pathology AI for spatial vascular decoupling on routine H&E whole-slide images.
- Access: Live Portal · bio.tools
Cylindrical Bessel K₀ reaction-diffusion solver and MSKCC survival validation (N = 604).
- Access: Live Portal · GHCR Docker Image
conda install -c bioconda spatial-continuum insitugame spatial-sanctuary
pip install spatial-continuum- Package Registries: PyPI · Bioconda
- Stack:
Python(NumPy,SciPy,pandas,scikit-learn,PyTorch,lifelines) ·Nextflow DSL2(nf-core) ·Snakemake·Galaxy (IUC)·Bioconda·Docker/Singularity·TypeScript·Three.js
Interactive 3D cardiology & pulmonology learning platform built with React, TypeScript, Three.js, and Tailwind CSS (3D cardiac anatomy, ECG telemetry simulator, auscultation audio library).
👉 Launch MedTerminal ↗
💼 Engineering Roots: Web3 & DeFi (Click to expand)
Before entering medical research, I built open-source blockchain and protocol software through the Arbitrage Inception organization:
- Arb-Inc All-in-Dex — DEX aggregation and cross-chain routing.
- Arbitrage Inception Earn — yield and lending vault integrations.
This deterministic systems background directly informs my approach to scientific software reliability.
Selected merged pull requests in upstream repositories:
- Snakemake — official wrappers: bio/spatialcontinuum #6233.
- Bioconda — scientific recipes: spatial-continuum #70930, insitugame #70893, spatial-sanctuary #70840.
- nf-core/modules — Nextflow modules: spatialcontinuum/cricalc #13487, insitugame #13471, ABRA2 #13039.
- awesome-single-cell — spatial transcriptomics curation #399.
- Awesome-AI4DigitalPathology — computational pathology tools #28.
- Developer Portfolios — portfolio showcase #4452.
- Angular — DevTools signal inspection fix #70986.
- viem — chain configurations #5108.
- Ethereum Lists — RPC additions #8730.
- DefiLlama — fee telemetry adapters #9838.
- 🏛️ Academic Affiliation: Department of Clinical Medicine and Surgery, School of Medicine, Università degli Studi di Napoli Federico II, Naples, Italy.
- 🎓 Academic Email: l.celebrano@studenti.unina.it
- ✉️ Personal Email: luca.celebrano1@gmail.com