Issues

• Why are they different?

  MRCIEU/TwoSampleMR#662 · Filter by author yikeshu0611 opened on Dec 10, 2025
  9

  

• [BUG]: Something is wrong when I run the "extract_outcome_data" function in the "Example 4. Effect of BMI on 103 diseases" session of the guide, details are below

  bug
  MRCIEU/TwoSampleMR#658 · Filter by author DengBopinghrb opened on Nov 10, 2025

• mv_extract_exposures runs too slow when the number of instruments is large

  MRCIEU/TwoSampleMR#637 · Filter by author ruoyao-shi opened on Jun 20, 2025

• [Suggestion]: Add parameters for which methods to use and add to the output mr_report()

  enhancement
  MRCIEU/TwoSampleMR#636 · Filter by author james-edward-hart opened on Jun 17, 2025

• mr_ruckers missing correction for underdispersion leads to p-values = 0

  MRCIEU/TwoSampleMR#630 · Filter by author arendma opened on May 14, 2025

• Difference between mv_multiple(instrument_specific = TRUE) and regular pairwise MR?

  MRCIEU/TwoSampleMR#628 · Filter by author mooreann opened on May 12, 2025

• Confusion: "extract_outcome_data" function without without a filter for significant SNPs (whose p_value<5*10e-8)

  MRCIEU/TwoSampleMR#625 · Filter by author kamisama0101 opened on May 6, 2025

• [BUG]: The se function for Wald ratio test in mr.R is wrong

  bug
  MRCIEU/TwoSampleMR#614 · Filter by author Yining97 opened on Mar 28, 2025
  1

• [BUG]: extract_instruments when set P1> 5e-08

  bug
  MRCIEU/TwoSampleMR#602 · Filter by author quanliustc opened on Mar 9, 2025
  11

• Error in extract_instruments function: missing 'origin' parameter

  MRCIEU/TwoSampleMR#594 · Filter by author lanxianmei opened on Feb 24, 2025

• steiger_pval is NaN

  MRCIEU/TwoSampleMR#585 · Filter by author amaa11 opened on Jan 22, 2025
  1

• [BUG]: Internal server error 500 when attempting to obtain a jwt from https://api.opengwas.io

  bug
  MRCIEU/TwoSampleMR#572 · Filter by author KonstanzeTan opened on Oct 28, 2024
  6

• [BUG]: Error in density.default(BetaIV.in, weights = weights, bw = h) : non-finite 'bw'

  bug
  MRCIEU/TwoSampleMR#570 · Filter by author Julie1130 opened on Oct 10, 2024
  8

• mv_extract_exposures_local possibility to include a dataframe already clumped

  enhancement
  MRCIEU/TwoSampleMR#569 · Filter by author AngeTKL opened on Oct 2, 2024

• [BUG]: Error in mv_extract_exposures_local()

  bug
  MRCIEU/TwoSampleMR#562 · Filter by author trprice08 opened on Sep 23, 2024
  1

• [BUG]: P value and 95% CI doesn't match

  bug
  MRCIEU/TwoSampleMR#558 · Filter by author Yvonnehuang1316 opened on Sep 4, 2024

• [BUG]: function power_prune() does not behave correctly when SNPs in a given outcome-study subset have varying sample sizes

  bug
  MRCIEU/TwoSampleMR#557 · Filter by author phageghost opened on Aug 29, 2024

• [BUG]: Locally reading the VCF file and online reading/extraction of the number of SNPs based on ID have differences.

  bug
  MRCIEU/TwoSampleMR#553 · Filter by author M-jk22 opened on Aug 14, 2024

• MR single snp analysis error

  enhancement
  MRCIEU/TwoSampleMR#535 · Filter by author tj0129edgar opened on Jul 11, 2024

• [BUG]: persistent mv_extract_exposures_local() bug

  bug
  MRCIEU/TwoSampleMR#520 · Filter by author bluscrubs opened on May 23, 2024
  1

• When using the mv_extract_exposures_local() function, why does the "id.exposure" column in the returned data frame contain some strange characters?

  bug
  MRCIEU/TwoSampleMR#518 · Filter by author hyq9588 opened on May 15, 2024
  2

• [BUG]: different results generate by mr()

  bug
  MRCIEU/TwoSampleMR#517 · Filter by author SunYidan2021 opened on May 14, 2024
  2

• [BUG]: Issues in running clump_data()

  bug
  MRCIEU/TwoSampleMR#507 · Filter by author eun-codeful opened on Apr 16, 2024
  3

• [BUG]: Can't generate leaveoneout plots and forest plots

  bug
  MRCIEU/TwoSampleMR#475 · Filter by author iikkalord opened on Mar 3, 2024
  1

• [BUG]: Fatal Data Error in IEU Open Gwas

  bug
  MRCIEU/TwoSampleMR#473 · Filter by author shaopopper opened on Feb 3, 2024
  1