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  • Hubrecht Institute
  • The Netherlands
  • Joined Oct 12, 2026

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nsarmadfar/README.md

Hi, I'm Nargess 👋

I'm a bioinformatician living in the Netherlands. I started out in plant breeding, working on QTL mapping for stress tolerance in wheat and rice. These days I mostly work with single-cell, cancer genomics and exposome data.

What I'm working on

  • MSc thesis (MARVEL): I'm combining several single-cell RNA-seq atlases of Arabidopsis root regeneration into one annotated cell-type map, and following how transcription factors change during regeneration.
  • Internship at the Hubrecht Institute: cancer genomics.

Projects

  • maternal-exposome: untargeted exposome analysis of maternal blood in a matched case-control design, from drift correction and mass-based annotation to conditional logistic regression and mixture models. Tested on a simulated study, then applied to pregnancy exposures in the HELIX data.
  • neoantigen-pipeline: from a tumour's somatic mutations and RNA-seq to the mutant peptides its own HLA class I molecules could present. Tested on simulated data, then run on the HCC1395 cell line.
  • smc-evolution: how the SMC proteins (cohesin, condensin, SMC5/6) evolved across 14 eukaryotes from all six supergroups, with a maximum-likelihood tree.
  • pathway-vae: a neural network for single-cell data in which every hidden variable is linked to a known pathway, so you can see directly which pathways are active in each cell. I tested it on simulated data and on human blood cells.

Skills

Python (scanpy, pandas, scikit-learn, PyTorch) · statistics (GLMs, QTL mapping) · Linux and HPC clusters (Slurm) · Git

Background

BSc and MSc in Plant Breeding at the University of Tehran, followed by research at the Agricultural Biotechnology Research Institute of Iran on QTL analysis under salt stress. Publication: Identification of wheat peduncle length QTLs as a criterion for heat tolerance.

I'm currently looking for a PhD position in bioinformatics. Feel free to contact me on LinkedIn.

Pinned Loading

  1. pathway-vae pathway-vae Public

    Pathway-informed neural network for single-cell RNA-seq, with benchmarks on simulated data and human blood cells

    Python

  2. maternal-exposome maternal-exposome Public

    Untargeted exposome analysis of maternal blood in a matched case-control design: QC and drift correction, mass-based annotation, conditional logistic regression and mixture models. Tested on simula…

    Python

  3. neoantigen-pipeline neoantigen-pipeline Public

    Finds candidate neoantigens from tumour somatic variants and RNA-seq (Ensembl annotation, 8-11mer peptides, self filter, MHCflurry). Tested on simulated data and the HCC1395 cell line.

    Python

  4. smc-evolution smc-evolution Public

    Phylogenetic analysis of SMC proteins (cohesin, condensin, SMC5/6) across 14 eukaryotes from all major supergroups

    Python