epigenetic-clock

Profiling epigenetic age in single cells

This program analyzes methylation levels at six CpG sites in the genome of blood cells to produce a prediction of an individual's biological age, using different machine learning and deep learning models.

Code associated with the findings in Duran-Ferrer, Nat Cancer 2020.

Regression models for "epigenetic clock" estimation of canine chronological age

24 epigenetic aging clocks (GrimAge V1/V2, Horvath, Hannum, PhenoAge, Ying, DunedinPoAm, DNAmTL…) as an installable, offline agent skill — pandas+numpy only.

Interpretable epigenetic clock links aging pathways and disease-specific methylation profiles

AntiEntropy models aging as stochastic entropy drift in CpG methylation state space. It integrates ElasticNetCV clocks, site-wise Shannon entropy 𝐻 ( 𝛽 ) H(β), PCA spectral decomposition, and HRF-based resonance to quantify negentropy gradients and simulate control-driven reversal toward low-entropy attractors.

Reproducible re-analysis on two human EPIC datasets asking whether partial epigenetic reprogramming reverts the causal-damage (DamAge) or the adaptive (AdaptAge) methylation layer — the two layers dissociate, and the dissociation replicates.

An R package of placental epigenetic clock to estimate aging by DNA-methylation-based gestational age

Why do dogs age so fast, and can AI help change it? A source-cited, cross-model-verified dossier: AlphaFold, IBM MAMMAL (with a video fact-check), AI for dogs & wolves, ageing biology, interventions, and ranked research paths. CC BY 4.0.

computational analysis of aging biomarkers at Harvard Aging Initiative

Introduction to machine learning with tidymodels

Epigenetic age prediction from DNA methylation data using elastic net regression (Horvath clock implementation)

epigenetic clock calibration

A three-language (Python/R/bash) 15-stage EWAS + ML pipeline on 689 real human blood methylomes (GSE42861, RA vs control, 485,512 CpGs): cell-type deconvolution, adjusted EWAS, chromatin-state context, epigenetic clock, leakage-controlled classifier, and molecular subtyping — all data downloaded live from NCBI GEO.

Poster presentation at the (American Society of Human Genetics) ASHG Virtual Meeting, 2021.

Reproducible DNA methylation aging clock pipeline with external validation and biological robustness diagnostics.

Simple Epigenetic Clock

En este repositorio se encuentran los scripts utilizados para el desarrollo del Trabajo Fin de Master en Bioinformática de la Universitat de València, titulado "Edad molecular endometrial en infertilidad: relojes epigenéticos y consecuencias funcionales"

Singapore National Precision Medicine Aging Study