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multiple-testing

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Solutions of applied exercises contained in "An Introduction to Statistical Learning with Applications in Python", by Tibshirani et al, edition 2023

  • Updated Oct 30, 2023
  • Jupyter Notebook

A statistical framework for detecting significant drug combination synergies in cancer. By leveraging tissue-specific reference null distributions across multiple synergy metrics, we compute empirical p-values to standardize synergy detection, uncover novel interactions, and enable rigorous evaluation of drug combinations.

  • Updated Mar 18, 2026
  • R
perception-xalpha-lite

Backtest overfitting audit for factor research: probability of backtest overfitting (PBO), deflated Sharpe ratio, point-in-time data, purged walk-forward. Searches published factor libraries and reports what actually survived costs.

  • Updated Aug 9, 2026
  • Python

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